ABAKAST-L

Mfd. by :- Aprazer healthcare (Fulfilled By : Magicine Pharma)

Abakast-L

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Magicine Pharma is registered with the Government Of NCT, India, Ministry Of Health in Government of Delhi, India, registration number DL-RAJ-122372 and as a wholesale distributor, department file No. 44208.

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Brand name: Abakast-L

Generic name: Abacavir/Lamivudine 

Strength: 600 mg/300 mg

Manufacturer: Aprazer

Dosage form: Tablet 

Indication: HIV

Storage: Store at room temperature. 

Overview

Abakast-L is a co-formulation of two antiretroviral agents known as Abacavir and Lamivudine. It is an anti-HIV medicine belonging to the class of Nucleotide analog reverse transcriptase inhibitors. It is used in the treatment of infection caused by HIV (human immunodeficiency virus) namely HIV-1 and HIV-2. The drug is also prescribed often for the treatment of AIDS (acquired immunodeficiency syndrome). 

Usage 

Abakast-L is administered as an oral-use tablet once daily (specifically, as per the doctor’s prescription). It should not be taken in doses greater or less than the prescribed strength. Take the Abakast-L tablet with a glass of water at the same time every day. Do not skip or overdose. Use effective contraception during antiretroviral therapy. 

Pharmacodynamics

Abacavir (Abakast-L):- It's an NRTI (nucleoside reverse transcriptase inhibitor) that works against the Human Immunodeficiency Virus Type 1 (HIV-1). It is phosphorylated into active metabolites that compete for viral DNA incorporation. Abacavir functions as a chain terminator of DNA synthesis by competitively inhibiting the HIV reverse transcriptase enzyme.

Lamivudine (Abakast-L):- It is a nucleoside reverse transcriptase inhibitor (NRTI) that inhibits viral DNA synthesis in the Human Immunodeficiency Virus Type 1 (HIV-1) and Hepatitis B (HBV) viruses. When phosphorylated, it can produce active metabolites that compete with viral DNA for inclusion. Lamivudine metabolites impede the action of the HIV reverse transcriptase enzyme by incorporating DNA.

Interactions

Abakast-L tablets may show significant interactions with the following medications, diseases, and alcohol:

With Medicines 

  • Bexarotene 

  • Zalcitabine 

  • Leflunomide  

  • Emtricitabine 

  • Teriflunomide 

With Diseases 

  • Hepatotoxicity 

  • Pancreatitis 

  • Renal impairment 

With Alcohol

Interaction of the Abakast-L tablets with alcohol is not known. Please contact your medical team before consuming any drink that contains alcohol.

Contraindications

Abakast-L tablets are not recommended for use in patients who are:

  • Hypersensitive 

  • Allergic to Abacavir

  • Allergic to Lamivudine

Abakast-L tablets may cause certain side effects after administration. Consult your general practitioner regarding the same. Do not take any over-the-counter regimen without a prescription.

  • Diarrhea 

  • Anxiety 

  • Headache

  • Trouble sleeping 

  • Loss of strength 

  • Fatigue 

  • Sore throat 

  • Swollen lymph nodes

  • Loss of appetite 

  • Seizures 

  • Cough 

  • Unusual weakness 

  • Blurred vision 

  • Loss of weight

  • Nausea

  • Insomnia

  • Fever 

  • Chest pain 

  • Allergic reaction 

  • Unusual tiredness 

  • Poor concentration 

  • Confusion 

  • Abnormal dreams 

  • Sensation of spinning

Take Abakast-L tablets as per the prescription given by your medical practitioner. Do not chew or cut these antiviral tablets. 

Missed Dose 

It is ideally advised to not skip any dose of Abakast-L tablets. However, if such a case happens, make sure to contact your medical practitioner. 

Overdose

It is ideally advised to not overdose on Abakast-L tablets. However, if such a case happens, make sure to call a poison helpline or emergency medical center.

  • Pregnancy
    In pregnant women, the use of Abakast-L tablets may cause harm to the unborn baby. Consult your medical practitioner for the right advice. 

  • Breastfeeding
    In nursing women, the use of Abakast-L tablets may cause harm to the baby. Consult your medical practitioner for the right advice.

  • Contraception
    Using contraceptives or birth control can be a better option during the therapy with Abakast-L since HIV can be transmitted easily via sexual intercourse.

  • Driving
    Abakast-L tablets may affect your ability to drive. Do not initiate driving if you feel dizzy or tired.

  • Alcohol
    Alcohol can have severe effects on the body when consumed with the Abakast-L tablets.

  • Kidney
    In patients with kidney disease, Abakast-L tablets should be administered with caution. 

  • Liver
    In patients with liver disease, Abakast-L tablets should be administered with caution.

Q1- What is Abakast-L?

Ans- Abakast-L is a co-formulation of two antiretroviral agents known as Abacavir and Lamivudine. It is used in the treatment of infection caused by HIV (human immunodeficiency virus)

Q2- What are the side effects of Abakast-L?

Ans- The common side effects of Abakast-L (Abacavir/Lamivudine) are diarrhea, anxiety, headache, fatigue, weakness, fever, chills, sore throat, insomnia, chest pain, confusion, abnormal dream, a sensation of spinning, etc. 

Q3- What happens if I miss a dose of Abakast-L?

Ans- It is ideally advised to not skip any dose of Abakast-L tablets. However, if such a case happens, make sure to contact your medical practitioner.

Q4- What happens if I overdose on Abakast-L?

Ans- It is ideally advised to not overdose on Abakast-L tablets. However, if such a case happens, make sure to call a poison helpline or emergency medical center.

Q5- Is Abakast-L safe for use in pregnant women?

Ans- In pregnant women, the use of Abakast-L tablets may cause harm to the unborn baby. Consult your medical practitioner for the right advice.

Q6- Is  Abakast-L safe for use in nursing women?

Ans- In nursing women, the use of Abakast-L tablets may cause harm to the baby. Consult your medical practitioner for the right advice.

Q7- What is the available strength of Abakast-L?

Ans- The fixed strength of each Abakast-L tablet is 600 mg/300 mg. 

Q8- How is Abakast-L administered?

Ans- Abakast-L (Abacavir/Lamivudine) tablets are administered orally with a glass of water. 

Q9-  Can I drive after taking Abakast-L?

Ans- Abakast-L tablets may affect your ability to drive. Do not initiate driving if you feel dizzy or tired.

Q10- Is alcohol consumption safe during Abakast-L therapy?

Ans- Alcohol can have severe effects on the body when consumed with the Abakast-L tablets.

Above Content has been reviewed by Professionals