PEGIHEP

Mfd. by :- Zydus Cadila (Fulfilled By : Magicine Pharma)

Pegihep

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Magicine Pharma is registered with the Government Of NCT, India, Ministry Of Health in Government of Delhi, India, registration number DL-RAJ-122372 and as a wholesale distributor, department file No. 44208.

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Medicine Details 

Brand name: Pegihep

Generic name: PegInterferon Alfa 2B 

Manufacturer: Zydus Cadila

Strength: 80mcg

Dosage: Injection 

Indication: Hepatitis C virus

Storage: Store in a refrigerator

Overview 

Pegihep injection is a prescription drug. It is used in the treatment of chronic hepatitis C virus (HCV) infection. DCGI has also proved this medicine for use in COVID patients. The initial Phase-III clinical trials of Pegylated Interferon Alpha 2b, PegiHep have shown promising results in the treatment of patients suffering from novel coronavirus. The results also indicated that when administered to the patients at an early stage, this medicine can help the patients in recovering faster, hindering the complications. 

Pharmacodynamics 

Peginterferon alfa-2b tends to inhibit viral replication in infected cells. It also suppresses cell proliferation and induces apoptosis. This compound works by exerting an anti-angiogenic effect. Pegihep injection also exerts immunomodulatory effects including:-

  • enhances phagocytic activity of macrophages
  • activates NK cells 
  • stimulates cytotoxic T-lymphocytes
  • upregulates of the Th1 T-helper cell subset 
  • raises body temperature 
  • decreases in leukocyte and platelet counts

Usage 

Pegihep comprises PegInterferon Alfa 2B and is available in the form of an injection. It is administered by a qualified health professional. This medicine works by modulating the immune system of the body. It is advisable to not self-administer Pegihep injection. The duration of treatment with Pegihep is decided by the health professional as per the severity of the condition.

Interactions 

Pegihep (PegInterferon Alfa 2B) injection may interact with the following medications and diseases severely. Make sure to consult a health professional regarding the same. 

Medicine Interactions 

  • Bupropion
  • Tizanidine
  • Clozapine
  • Tramadol
  • Leflunomide

Disease Interactions 

  • Lung disease 
  • Eye disorder 
  • Kidney disease 
  • Bone marrow suppression 
  • Diabetes Mellitus
  • Colitis
  • Thyroid disorders
  • CNS disorders
  • Cardiovascular disease
  • Autoimmune disorders

Alcohol Interaction

  • It is not known whether alcohol interacts with Pegihep (PegInterferon Alfa 2B) injection or not. Consult a physician. 

Contraindications 

Do not administer Pegihep (PegInterferon Alfa 2B) injection in the following circumstances: 

  • Hypersensitivity 
  • Allergy to PegInterferon Alfa 2B 
  • Allergy to any inactive ingredient of Pegihep
  • Autoimmune hepatitis
  • Liver cirrhosis

Side Effects 

  • Fatigue 
  • Headache 
  • Stomach pain
  • Diarrhea 
  • Viral infection
  • Inflammation of the mouth
  • Nervousness 
  • Sore throat
  • Difficulty in sleeping 
  • Indigestion 
  • Lack of concentration 
  • Dryness in mouth
  • Dizziness 
  • Cough 
  • Blurred vision 
  • Agitation
  • Anxiety
  • Loss of appetite 
  • Chills 
  • Fever 
  • Hoarseness 
  • Tiredness 
  • Dark-colored stools 
  • Weakness 
  • Depression 
  • Dry skin 
  • Muscle ache  

 

Note:- Contact a health professional if side effects occur and worsen your health condition.

Normal Dose 

Pegihep (PegInterferon Alfa 2B) injection is administered by a qualified health professional under the supervision of a medical professional in a clinical setup. It is advisable to not self-administer Pegihep injection.

Missed Dose 

In case you miss a dose of Pegihep (PegInterferon Alfa 2B) injection, consult a health professional right away. It is advisable to not change the dose strength to cope with the missed dose. 

Overdose

In case of an overdose, call an emergency medical helpline right away. Do not delay or ignore. Overdose can worsen your medical condition and lead to adverse events. Get supportive care from your nearest healthcare provider. 

Warnings for Females 

  • Pregnancy: Use of Pegihep (PegInterferon Alfa 2B) injection is not primarily recommended in pregnant women. It is advisable to be aware of the risks and benefits before administering. 
  • Breastfeeding: Use of Pegihep (PegInterferon Alfa 2B) injection is not primarily recommended in lactating women. It is advisable to be aware of the risks and benefits before administering.

Precautions 

  • Contraception: The use of effective contraception is advised during Pegihep therapy to hinder unwanted pregnancy. 
  • Heart patients: Use of Pegihep injection in heart patients may not be safe. It is advised to administer with utmost caution. 
  • Operating heavy machines: After administering Pegihep (PegInterferon Alfa 2B) injection, it is advisable to not undertake any activity that requires concentration like operating heavy machinery

Cautions

  • Do not self-administer Pegihep (PegInterferon Alfa 2B) injection. 

  • Do not miss a dose or overdose. 

  • Do not consume alcohol during Pegihep therapy because the interaction of alcohol with this injection is unknown.  
  • Do not drive after taking Pegihep (PegInterferon Alfa 2B). 

Q1. What is Pegihep (PegInterferon Alfa 2B)?

Ans. Pegihep injection is a prescription drug. It is used in the treatment of chronic hepatitis C virus (HCV) infection. DCGI has also proved this medicine for use in COVID patients.

 

Q2. How to use Pegihep (PegInterferon Alfa 2B)?

Ans. Pegihep (PegInterferon Alfa 2B) injection is administered by a qualified health professional under the supervision of a medical professional in a clinical setup. It is advisable to not self-administer Pegihep injection.

 

Q3. Does Pegihep (PegInterferon Alfa 2B) cause any side effects?

Ans. The side effects of Pegihep injection are fever, chills, difficulty in sleeping, stomach pain, headache, dizziness, dark-colored stools, cough, sore throat, nervousness, drowsiness, blurred vision, etc. 

 

Q4. What happens if I overdose Pegihep (PegInterferon Alfa 2B)?

Ans. In case of an overdose, call an emergency medical helpline right away. Do not delay or ignore. Overdose can worsen your medical condition and lead to adverse events.

 

Q5. Is it safe to use Pegihep (PegInterferon Alfa 2B) during pregnancy?

Ans. Use of Pegihep (PegInterferon Alfa 2B) injection is not primarily recommended in pregnant women. It is advisable to be aware of the risks and benefits before administering.

 

Q6. Is it safe to use Pegihep (PegInterferon Alfa 2B) during breastfeeding?

Ans. Use of Pegihep (PegInterferon Alfa 2B) injection is not primarily recommended in lactating women. It is advisable to be aware of the risks and benefits before administering.

 

Q7. Is it safe to drive after taking Pegihep (PegInterferon Alfa 2B)?

Ans. Do not drive after taking Pegihep (PegInterferon Alfa 2B) injection as this injection may cause certain adverse effects like dizziness and blurred vision. 

 

Q8. In what strength is Pegihep (PegInterferon Alfa 2B) available?

Ans. Pegihep (PegInterferon Alfa 2B) injection is available in the strength of 80mcg. 

 

Q9. Is alcohol consumption safe during the course of Pegihep (PegInterferon Alfa 2B)?

Ans. Do not consume alcohol during Pegihep therapy because the interaction of alcohol with this injection is unknown.

 

Q10. How to store Pegihep (PegInterferon Alfa 2B)?

Ans. Store Pegihep (PegInterferon Alfa 2B) in a refrigerator. 

Above Content has been reviewed by Professionals