ATRIANCE

Mfd. by :- Novartis  (Fulfilled By : Magicine Pharma)

ATRIANCE

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Magicine Pharma is registered with the Government Of NCT, India, Ministry Of Health in Government of Delhi, India, registration number DL-RAJ-122372 and as a wholesale distributor, department file No. 44208.

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Medicine Details 

Brand Name:- Atriance  

Generic Name:- Nelarabine 

Manufacturer:- Novartis 

Strength:- 5mg/ml 

Dosage:- Injection 

Indications:- Blood Cancer 

Overview 

Atriance injection, comprising Nelarabine, is an anti-cancer medication. It is used to treat certain types of Blood Cancers including leukemia and lymphoma. This medication belongs to a group of drugs known as antineoplastic agents. These agents are used to kill the cancerous cells in the body. Atriance (Nelarabine) is a chemotherapeutic drug. It is not recommended for use during pregnancy and breastfeeding, unless necessary.  

Pharmacodynamics  

The active ingredient of Atriance is Nelarabine. The compound is a prodrug of the cytotoxic deoxyguanosine analog 9-ß-D-arabinofuranosyl guanine. This compound is demethylated by adenosine deaminase to ara-G. The formulation is transported then into cells, where it starts to undergo three phosphorylation steps. This results in the production of ara-G triphosphate (ara-GTP). Ara-G converts to ara-G monophosphate (ara-GMP) in the first phosphorylation step. Ara-GMP is monophosphorylated by deoxyguanosine kinase and deoxycytidine kinase to ara-G diphosphate, and subsequently to the active ara-G triphosphate (ara-GTP). It exerts a pharmacological effect. Pre-clinical studies have shown that targeted T-cells possess marked sensitivity to the agent. 

Usage of Atriance  

Atriance (Nelarabine) injection is a prescription medicine. This medicine is an injection available in the strength of 5mg/ml. It is used in the treatment of:-  

  • T-cell Acute Lymphoblastic Leukaemia, a type of Leukaemia.  

  • T-cell Lymphoblastic Lymphoma, a type of Lymphoma. 

Interactions

Alcohol  

Its interaction with alcohol is not known. Consult a qualified medical professional before consuming alcohol during the administration of Atriance (Nelarabine) injection.  

Medicines  

  • Diltiazem Hydrochloride SR (diltiazem) 

  • Cytoxan (cyclophosphamide) 

  • Clotrimazole Troche (clotrimazole) 

  • L-Arginine (arginine) 

  • L-Carnitine (levocarnitine) 

  • Co-trimoxazole (sulfamethoxazole / trimethoprim) 

  • Metoprolol Tartrate (metoprolol) 

  • Paracetamol (acetaminophen) 

  • Heparin Sodium (heparin) 

Diseases 

  • Neurotoxicity  

  • Vaccination  

  • Liver dysfunction 

  • Renal impairment 

  • Bone marrow depression 

Normal Dose  

A qualified healthcare professional or nurse will administer Atriance (Nelarabine) injection to you by a drip into your vein. Do not try self-administration.  

Missed Dose 

If you miss a scheduled dose of Atriance (Nelarabine) injection, consult your doctor for ways to cope with the skipped dose.  

Overdose 

Overdose may cause some severe reactions. If such side effects occur, consult your healthcare provider or an emergency helpline.  

Warnings and Precautions  

General Warnings 

  • A qualified healthcare professional or nurse will administer Atriance (Nelarabine) injection to you by a drip into your vein. Do not try self-administration.  

  • Make your doctor aware of the diseases you have and the medicines you take.  

  • Do not skip a scheduled dose of Atriance (Nelarabine) injection.  

  • Regular monitoring of blood pressure may be required in some patients.  

Warnings for Females 

  • Pregnancy  

  • During pregnancy, taking Atriance (Nelarabine) injection may cause fetal harm to the unborn baby. 

  • Breastfeeding  

  • During breastfeeding, taking Atriance (Nelarabine) injection may cause fetal harm to the newborn baby. 

Special Precautions 

  • Alcohol Consumption 

  • Its interaction with alcohol is not known. Consult a qualified medical professional before consuming alcohol during the administration of Atriance (Nelarabine) injection.  

  • Driving  

  • It may not be safe to drive after taking Atriance (Nelarabine) injection due to side effects like dizziness and blurred vision.  

  • Kidney/Liver disease  

  • If you are suffering from a liver/kidney disease, it is important to consult a doctor about the same and know the risks of taking Atriance (Nelarabine) injection before its administration.  

Q1. What is Atriance (Nelarabine)? 

Ans. Atriance injection, comprising Nelarabine, is an anti-cancer medication. It is used to treat certain types of Blood Cancers including leukemia and lymphoma.  

 Q2. What are the side effects of Atriance (Nelarabine) injection? 

Ans. The side effects of Atriance (Nelarabine) injection are fever, chills, anemia, blurred vision, muscle weakness, chest pain, difficulty in breathing, stomach ache, constipation, etc. 

 Q3. In what strength is Atriance (Nelarabine) injection available? 

Ans. Atriance (Nelarabine) injection is available in the strength of 5mg/ml.  

 Q4. What is the salt composition of Atriance injection? 

Ans. The salt composition of Atriance injection is Nelarabine 5mg/ml.  

 Q5. Can I drink alcohol with Atriance (Nelarabine)? 

Ans. Its interaction with alcohol is not known. Consult a qualified medical professional before consuming alcohol during the administration of Atriance (Nelarabine) injection. 

 Q6. Can I drive after taking Atriance (Nelarabine) injection? 

Ans. It may not be safe to drive after taking Atriance (Nelarabine) injection due to side effects like dizziness and blurred vision.  

 Q7. Is it safe to take Atriance (Nelarabine) in liver disease? 

Ans. Several dose adjustments may be needed if you are suffering from liver disease. Contact a qualified doctor for the same.  

 Q8. Is it safe to take Atriance (Nelarabine) injection during pregnancy? 

Ans. During pregnancy, taking Atriance (Nelarabine) injection may cause fetal harm to the unborn baby.  

 Q9. Is it safe to take Atriance (Nelarabine) injection during breastfeeding? 

Ans. During breastfeeding, taking Atriance (Nelarabine) injection may cause fetal harm to the newborn baby. 

Q10. How should I take Atriance (Nelarabine) injection? 

Ans. A qualified healthcare professional or nurse will administer Atriance (Nelarabine) injection to you by a drip into your vein. Do not try self-administratio

Above Content has been reviewed by Professionals