TS-ONE

Mfd. by :- Taiho (Fulfilled By : Magicine Pharma)

TS-ONE

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Magicine Pharma is registered with the Government Of NCT, India, Ministry Of Health in Government of Delhi, India, registration number DL-RAJ-122372 and as a wholesale distributor, department file No. 44208.

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DESCRIPTION

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PACKAGE

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Brand name:- TS-ONE

Composition:- Tegafur, Gimeracil, Oteracil Potassium

Manufacturer:- Taiho  

Dosage form:- Capsule

Strength:- 20mg

Packaging:- Strip 

Indication:- Gastric Cancer 

Storage:- Store below 25°C.

Overview

TS-ONE Capsule is an anti-cancer medicine used in the treatment of Gastric Cancer with other medications like Cisplatin. It is also used in the treatment of head and neck cancer, lung, biliary tract, breast, pancreatic, and colorectal cancer. TS-ONE capsules comprise three agents namely tegafur (FT), gimeracil (CDHP), and oteracil potassium (Oxo). It is a prescription medicine, used with other medications to treat certain types of cancers. It is not prescribed for use in pregnant and breastfeeding women. This medicine may cause certain side effects. It is important to know the relevant ways to manage the side effects before the administration of the capsules. Make sure to consult your physician. 

Pharmacodynamics 

The antitumor activity of TS-ONE after its administration (orally) is based on 5-fluorouracil (5-FU) that tends to appear gradually in the body via the transformation of FT. CDHP increased the 5-FU’s concentration, which is converted from FT, by selectively and reversibly inhibiting DPD, a catabolic enzyme of 5-FU, which is particularly distributed in the liver. 5-fluoronucleotides, phosphorylated metabolites of 5-FU, are highly maintained in tumor tissues, thereby enhancing the antitumor activity in proportion to the increase in the concentration of 5-FU in the body. Oxo works to selectively inhibit the production of 5-fluoronucleotides from 5-FU by enabling the distribution in the gastrointestinal tissue as a result of the medicine’s administration, and selectively inhibiting orotate phosphoribosyltransferase.

Contraindications 

TS-ONE Capsules are not indicated for use in the following cases. However, if its use can not be avoided during any of these situations, make sure to know the risks associated with the medicine before the administration. 

  • Hypersensitivity 

  • Pregnancy 

  • Lactation (Breastfeeding women)

  • Allergy

    • Tegafur  

    • Gimeracil 

    • Oteracil potassium

    • Any other ingredient of the medicine

 

Side effects 

TS-ONE Capsules may cause certain side effects. Some of the common and serious side effects are stated below. Make sure to contact your healthcare professional if side effects occur after administration or last longer than usual.

Common side effects 

  • Fever 

  • Headache 

  • Chills 

  • Nausea 

  • Sore throat 

  • Malaise 

  • Dehydration

  • Diarrhea 

  • Abdominal pain

  • Speech disorder

  • Sensory disturbance 

  • Tiredness 

  • Lack of energy 

  • Vomiting 

  • Irregular heartbeat 

  • Unusual bleeding 

  • Bruising 

  • Skin rash 

  • Itching 

  • Yellowing of skin

  • Mouth sores 

Serious side effects

  • Thrombocytopenia 

  • Hemolytic anemia

  • Severe hepatic disorder

  • Dyspnea 

  • Shortness of breath 

  • Cardiac failure 

  • Palpitation 

  • Chest pain 

  • Gastrointestinal ulcer

  • Hemorrhage 

  • Low red blood cell count

  • Low white blood cell count

  • Dark-colored stools

  • Dark-colored urine 

Dosage

Normal Dose 

The doctor will recommend the dose strength and frequency of your dose as per your health condition and the body’s tolerance. Take the capsule as a whole with water. Do not crush or cut it. 

Missed Dose 

If you miss a dose of TS-ONE Capsule, make sure to contact your healthcare professional before taking the next dose. Do not try to cope with the missed dose by doubling the strength of your next dose. 

Overdose

Overdose may cause certain adverse symptoms. If you experience such symptoms, make sure to contact your healthcare professional before taking any other step. If symptoms worsen your medical condition, seek emergency help from a medical center/hospital. 

 

Warnings and Precautions 

Special Population

  • Pregnancy 

    • TS-ONE Capsules are not indicated for use in pregnant women. Severe adverse reactions may be caused if this medicine is administered during pregnancy. 

  • Nursing women 

    • Nursing women should not take TS-ONE Capsules as this medicine may cause a fatal effect on the growth of the baby and may also lead to toxicity. 

  • Kidney disease 

    • In patients having known kidney disease, TS-ONE Capsules should be administered either cautiously or be avoided. 

  • Liver disease 

    • In patients having known liver disease, TS-ONE Capsules should be administered either cautiously or be avoided.

General Warnings 

  • Driving 

    • TS-ONE Capsules may cause dizziness or lack of concentration. Therefore, it is important to avoid driving or any other activity that needs high concentration. 

  • Alcohol consumption 

    • Consumption of alcohol with TS-ONE Capsule should be avoided. It may cause a serious effect on the health of the patient. 

  • Smoking 

    • Smoke (of any kind) should be avoided, in general. However, its interaction with this medication is not discovered yet. Consult your physician.

Q1- What is TS-ONE used for?

Ans- TS-ONE is used in the treatment of Gastric Cancer with other medications like Cisplatin. It is also used in the treatment of head and neck cancer, lung, biliary tract, breast, pancreatic, and colorectal cancer. 

 

Q2- What is the storage condition for TS-ONE?

Ans- Store TS-ONE Capsules below 25°C. Keep this medicine away from children. 

 

Q3- How should I take TS-ONE?

Ans- Take the capsule as a whole with water. Do not crush or cut it. 

 

Q4- Is smoking safe during the course of TS-ONE?

Ans- Smoke (of any kind) should be avoided, in general. However, its interaction with this medication is not discovered yet. Consult your physician. 

 

Q5- What are the side effects of TS-ONE capsules?

Ans- Some of the common side effects of TS-ONE capsules are fever, headache, nausea, vomiting, chills, shortness of breath, etc. Make sure to contact your healthcare professional if side effects occur after administration or last longer than usual.

 

Q6- What is the available strength of TS-ONE?

Ans- TS-ONE Capsule is available in the strength of 20mg. 

 

Q7- Can I take TS-ONE capsules during pregnancy?

Ans- TS-ONE Capsules are not indicated for use in pregnant women. Severe adverse reactions may be caused if this medicine is administered during pregnancy.

 

Q8- Can I take TS-ONE capsules during breastfeeding?

Ans- Nursing women should not take TS-ONE Capsules as this medicine may cause a fatal effect on the growth of the baby and may also lead to toxicity. 

 

Q9- Is it safe to drink alcohol during the course of TS-ONE?

Ans- Consumption of alcohol with TS-ONE Capsule should be avoided. It may cause a serious effect on the health of the patient. 

 

Q10- Is it safe to drive after taking a TS-ONE capsule?

Ans- TS-ONE Capsules may cause dizziness or lack of concentration. Therefore, it is important to avoid driving or any other activity that needs high concentration.

 

Above Content has been reviewed by Professionals