GEFTINAT

Mfd. by :- NATCO Pharma Ltd (Fulfilled By : Magicine Pharma)

Geftinat

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Magicine Pharma is registered with the Government Of NCT, India, Ministry Of Health in Government of Delhi, India, registration number DL-RAJ-122372 and as a wholesale distributor, department file No. 44208.

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DESCRIPTION

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PACKAGE

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Brand name- Geftinat 

Generics- Gefitinib 

Manufacturer- NATCO Pharma Ltd.  

Dosage form- Tablet 

Route of Administration- oral 

Strength- 250mg 

Composition- Gefitinib 

Packaging- Bottle 

Indication- non-small cell lung cancer (NSCLC). 

Storage- Store at room temperature (10-30°C) 

Class of drug- Anti-Neoplastics  

Mechanism of Action 

It works by blocking the action of abnormal protein that signals cancer cells to multiply. This in turn helps to slow or inhibit the spread of cancer cells 

Side effects- 

The most common side effects of geftinat include nausea, rash, vomiting and weight loss. It may cause severe diarrhea, drink plenty of fluids or consult the doctor if it happens. It makes the patient sensitive towards sunlight, hence wear protective clothing or use sunscreen while going out.  

Pharmacodynamics 

It is study of drug effects and what the medicine does to the body 

It inhibits the intracellular phosphorylation of tyrosine kinase associated with epidermal growth factor (EGFR). 

Pharmacokinetics 

Study of what body does to the medicine.Geftinat is absorbed slowly after oral administration as it has bioavailability of 60%. Elimination is through metabolism (primarily CYP 3A4) and excretion in feces.  

Bioavailability rate 

Geftinat is slowly absorbed, with peak plasma levels in 3-7 hours after dosing and mean oral bioavailability of 60% 

Shelf life  

Shelf life is the time period over which the concentration of the active medicinal ingredient in the formulation lowers by 10 percent from its value at time of manufacture. 

Its shelf life is 26 months 

Usage 

Which disease area  
non-small cell lung cancer (NSCLC)  

Substitutes 

GEFIMIPSA 250MG CAPSULE-  Ark Life Sciences Pvt Ltd 

Geficad 250mg Tablet-  Cadila Pharmaceuticals Ltd 

Geffon 250Mg Tablet-  Zydus Cadila 

Chemogef 250Mg Tablet- Neon Laboratories Ltd 

Geftistar 250mg Tablet-  Lupin Ltd 

Alternate brands 

Gefticip 250 mg Tablet (CIPLA Ltd.) 

Geftifos 250 mg Tablet (Torrent Pharmaceuticals Ltd.) 

Zefotib 250 mg Tablet (Alkem Laboratories Ltd.) 

Zufinib 250 mg Tablet (Zuventus Healthcare Ltd.) 

Precaution 

Consult your doctor before taking this medicine, if you: 

Experience unexplained shortness of breath, cough, and fever that comes on suddenly. These could be symptoms of a serious lung condition. 

Have severe or continuing diarrhea that lasts up to 14 days. 

Experiencing adverse skin reactions like blistering, peeling, or loosening of the skin, red skin lesions, severe acne or skin rash, sores or ulcers on the skin  
Side effects 
         Common side effects    

  •  Diarrhea 

  • Fever 

  • Allergic skin reaction 

  • Nausea and Vomiting 

  • Increase in liver enzyme levels 

  • Eye irritation 

  • Difficulty in breathing 

  • Abdominal pain 

  • Sore throat 

  • Redness around fingernails 

Serious side effects 

Unusual bleeding (in cough and urine),eye irritation or pain, or swelling of the ankles or feet 

Dosage 

Missed dose 

If the patient misses a dose of medicine, skip it and continue with the normal schedule. No need to double the dose 

Overdose 

Get the emergency medical treatment and contact your physician  

Warnings 


General warning and precautions 

Do not take antacids (to reduce the acid level of your stomach) 2 hours before or 1 hour after administering geftinat. 

Diarrhea can occur as a side effect. Drink plenty of fluids and inform the doctor in case if it doesn't stop or there is blood in stools. 

Cautions 

It is usually taken on an empty stomach once a day, at least 1 hour before or 2 hours after eating a meal or snack. Take geftinat at around the same time every day. 

Q What is Gaftinat 

Geftinat 250 mg Tablet is an anticancer medicine used for the treatment of cancer of the lungs. Take the medicine under the supervision of a qualified physician. This medicine is not recommended for use in patients with lung and liver diseases 

Q How Gaftinat works 

Epidermal growth factor receptors (EGFR) are expressed on the lung cancer cell surfaces that regulate their growth. This medicine works by binding the chemical messenger, EGFR, thus inhibits the cancer signaling pathways. This is how the medicine inhibit further growth of the cancer cells. 

Q What are the side effects 

Side Effects of Gaftinat include nausea, rash, vomiting and weight loss. It may cause severe diarrhea, drink plenty of fluids or consult the doctor if it happens. It makes the patient sensitive towards sunlight, hence wear protective clothing or use sunscreen while going out. 

Q In what strength it is available 

It is available in 250mg 

Q What should I avoid while receiving this medicine 

Avoid grapejuice and smoking while taking the medication 

Q How to use Giftinat 

Giftinat 250mg Tablet is a pill to be administered orally, once a day without food as prescribed by the concerned specialist. Take Giftinat 250 mg Tablet empty stomach, at least 1 hour before or 2 house after meals. Take it the same time each day so that you remember when to take it 

Q What happens when I miss a dose 

If you miss a dose of medicine, skip it and continue with the normal schedule. No need to double the dose 

Q Does this medicine effects liver function 

There is no data available. Consult doctor before consuming the medicine. 

Q Can I drive after taking this medicine 

Do not drive if you have any symptoms that affect your ability to concentrate and react. Geftinat Tablet make you feel weak. This may affect your driving ability. 

Q Can I take this medicine during pregnancy 

Geftinat tablet is not safe to use during pregnancy as there is proven evidence of risk to the developing baby.  

Q Can I take this medicine during breast-feeding 

Geftinat tablet is probably not safe to use during breastfeeding. 

Q Can I consume Alcohol while taking this medicine 

It is not safe to consume Alcohol 

Q Does it affect kidney functions 

There is no affects on the kidney functions 

Q What are the storage conditions 

Store the medicine at room temperature (10-30°C) 

Interactions 

Medicine interaction 

  • Warfarin 

  • Ranitidine, cimetidine, famotidine, omeprazole, lansoprazole, rabeprazole) 

  • Vinorelbine 

  • NSAIDs (such as ibuprofen, naproxen), corticosteroids  

Disease interaction 

The drug is contraindicated in patients who have suffered or are suffering from glaucoma, cardiac disorders, lungs or liver disorders or renal malfunctioning

 Alcohol interaction 

Alcohol may cause interactions, consult your doctor 

Food interaction 

The patient should also avoid grapefruit and grapefruit juice while taking the medicine. Take with or without food. The absorption is unaffected by food. 

Above Content has been reviewed by Professionals