DOXORUBICIN 

Mfd. by :- Pfizer (Fulfilled By : Magicine Pharma)

 Doxorubicin 

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Magicine Pharma is registered with the Government Of NCT, India, Ministry Of Health in Government of Delhi, India, registration number DL-RAJ-122372 and as a wholesale distributor, department file No. 44208.

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Brand Name:- Doxorubicin   

Generic Name:- Doxorubicin Hydrochloride 

Manufacturer:-  Pfizer 

Dosage Form:- Injection 

Strength:- 200mg/100ml 

Composition:- Doxorubicin Hydrochloride 

Packaging:- 1vial  

Indication:- Ovarian cancer, Kaposi’s sarcoma, and multiple myeloma  

Storage:- Store this medicine in the refrigerator. 

Overview 

Doxorubicin is used to treat certain types of cancer (ovarian cancer, AIDs related to Kaposi’s sarcoma, and multiple myeloma). This medication belongs to the group of antineoplastics (cancer-fighting medications) known as anthracyclines. Doxorubicin medicine works by slowing or stopping the growth of cancer cells. Take this medicine as prescribed by your medical advisor. Dosage is based on your medical condition and your response to the treatment. This medicine is given as an infusion into your vein. Do not self administer this medicine. Do not take this medicine in the wrong way as it may lead to some severe side effects. If you experience any symptoms while receiving this medicine, inform your doctor immediately. 

Pharmacodynamics of Doxorubicin 

Doxorubicin is an antineoplastic in the anthracycline class. Doxorubicin forms complexes with DNA by intercalation between base pairs, and it inhibits topoisomerase II activity by stabilizing the DNA-topoisomerase II complex, preventing the relegation portion of the ligation-relegation reaction that topoisomerase II catalyzes. 

Usage of Doxorubicin 

It is an anti-cancer medication that is used for the treatment of blood, ovaries, and Kaposi’s sarcoma (a type of cancer that causes lesions to grow below the surface of the skin, lymph nodes, etc.)  It can lower blood cells that help your body to fight infections. This medicine must be given slowly as an infusion into the vein. It is important to take this medicine exactly as prescribed by your medical advisor. Do not skip or miss the dosing schedule. It is advisable not to change or stop the dose without taking suggestions from your doctor. Do not use this medicine if you are pregnant. 

Side effects of Doxorubicin 

This medicine may cause some major and minor side effects. Discuss the risks and benefits of this medication with the doctor before starting the treatment.  

Common side effects  

  • Severe headache  

  • Rash  

  • Sore throat  

  • Nausea  

  • Fever  

  • Vomiting  

  • Pain at the injection site  

  • Dizziness  

  • Muscle pain  

  • Diarrhea  

  • Hair loss  

  • Cough  

  • Loss of appetite  

  • Constipation  

  • Blisters  

  • Anxiety  

  • Shortness of breath  

  • Tiredness 

  • Abdominal pain  

  • Chest pain  

  • Shortness of breath  

  • Irregular heartbeat  

  • Back pain  

  • Difficulty in urination  

  • Pale skin 

  • Fever with chills  

  • Dehydration  

  • Mouth ulcers  

  • Painful blisters on hand and feet  

  • Low blood pressure  

  • Pin when eating and swallowing  

  • Red spots on the skin  

  • Drowsiness  

  • Low red and white blood cells  

  • Blurred vision  

  •  Red and itchy eyes  

Note- immediately contact your doctor if any side effects occur.  

Dosage of  Doxorubicin

Take this injection as prescribed by your doctor. The injection is given as an infusion into your vein by a doctor or nurse. Do not self administer.  

Missed dose  

  • It is advisable not to miss a dose. If you miss an appointment for a scheduled dose of this medicine, contact your doctor immediately.  

Overdose  

  • In case of an overdose, the doctor will provide emergency medical treatment.  

Warnings of  Doxorubicin

Before starting treatment with Doxorubicin, please inform your doctor about your previous medical history. If you experience any symptoms while receiving this medication, do not ignore those symptoms because it may lead to higher risk.  

  •  Contraception  

  • Use effective methods of contraception to prevent pregnancy while taking this medicine.  

  • Children and adolescents  

  • This medicine is not advisable for use in children and adolescents. 

Warnings for female  

  • Pregnancy  

  • Do not use Doxorubicin if you are pregnant or planning to become pregnant.  Avoid this medication at the time of pregnancy.  

  • Breastfeeding  

  • This medicine is not recommended in breastfeeding unless it is necessary. Please consult your medical advisor before starting treatment with this medication. 

Precautions of  Doxorubicin

  • This medicine may increase the risk of heart failure.  

  • Close monitoring of blood cell count and body temperature is necessary while receiving this medication.  

  • The use of this medicine may decrease the white blood cell count in patients.  

  • Do not receive any vaccines while having treatment with this medicine.  

  • Avoid contact with people who have infections.  

  • Close monitoring of symptoms like mouth ulcers and bleeding is required.  

Cautions of  Doxorubicin

  • Not safe for pregnant women.  

  • Do not drive or operate heavy machinery.  

  • Do not self administer this medicine. 

  • Do not breastfeed while receiving this medication.  

  • Do not start the treatment if the blood cell count is low

Q1. What is Doxorubicin?  

Ans. Doxorubicin is an anti-cancer drug that belongs to a class of medication like anthracyclines. This medication works by slowing or stopping the growth of cancer cells. 

Q2. How does Doxorubicin work?  

Ans. Doxorubicin works by blocking the effect of an enzyme called topoisomerase II that helps cancer cells to divide and grow.  

Q3. What are the side effects?  

Ans. Some common side effects are:- severe headache, nausea, sore throat, vomiting, dehydration, anxiety, chest pain, rash, irregular heartbeat, shortness of breath, etc.  

Q4. In what strength is it available?  

Ans. It is available in the strength of 200mg/100ml.  

Q5. What should I avoid while receiving this medication?  

Ans. Avoid contact with people who have infections and follow your doctor’s instructions about any restriction.  

Q6. What happens if I miss a dose?  

Ans. If you miss a scheduled dose of this medicine, contact your doctor immediately.  

Q7. What are self-care tips?  

Ans. Keep yourself hydrated and maintain good nutrition.  

Q8.  How is Doxorubicin given?  

Ans. It is given as an infusion into the vein. Do not self administer this medicine.  

Q9.  Can I consume alcohol while taking this medicine?  

Ans. Please consult your doctor before consuming alcohol.  

Q10. Can I take this medicine during pregnancy? 

Ans. This medicine is not recommended for pregnant women.  

Q11. Can I drive after taking this medicine?  

Ans. This medicine may affect your vision. Do not drive if any symptoms occur.  

Q12.  Does this affect liver function?  

Ans. Please consult your doctor before consuming this drug.  

Q13. Can I take this medicine during breastfeeding?  

Ans. This medicine is not recommended during breastfeeding unless it is necessary.  

Q14. What are the storage conditions?  

Ans. Store this medicine in the refrigerator.  

Interactions of Doxorubicin 

Interactions may change how your medication works and increase the risk for side effects. Don’t forget to disclose your previous medical history with the doctor.  

Medicine interaction  

  • Methadone  

  • Diltiazem  

  • Pimozide  

  • Tofacitinib  

  • Dexamethasone  

  • Amiodarone  

Disease interaction  

  • Congestive heart failure  

  • Infections  

  • Hepatic dysfunction  

  • Myelosuppression  

Alcohol interaction  

  • Interaction with alcohol is unknown. Please consult your doctor before consuming alcohol.  

Contraindications of Doxorubicin  

  • Use of this medicine is not recommended for patients with a known allergy to Doxorubicin hydrochloride injection. 

  • This medicine is not recommended in patients known to be hypersensitive.  

Above Content has been reviewed by Professionals