TOFAJAK

Mfd. by :- Cipla (Fulfilled By : Magicine Pharma)

Tofajak

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Magicine Pharma is registered with the Government Of NCT, India, Ministry Of Health in Government of Delhi, India, registration number DL-RAJ-122372 and as a wholesale distributor, department file No. 44208.

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Medicine details 

Brand name: Tofajak

Generic name: Tofacitinib

Strength: 5mg

Manufacturer: Cipla 

Dosage form: Tablet 

Indication: Rheumatoid arthritis

Storage: Store at room temperature 

Overview

Tofajak tablets is a prescription regimen comprising Tofacitinib. It is used in the treatment of patients suffering from severely active rheumatoid arthritis and psoriatic arthritis. This medication works by reducing the signs and symptoms of arthritis in patients who have shown no response to methotrexate. It helps to decrease the swelling in adult patients (over the age of 18 years). Tofajak is also used to treat patients with ulcerative colitis. Tofajak (Tofacitinib) is available in the form of oral-use tablets in the strength of 5mg. 

Pharmacodynamics

Tofacitinib, the active ingredient of Tofajak tablets, is a partial and reversible Janus kinase (JAK) inhibitor that works to prevent the body from responding to cytokine signals. By inhibiting JAKs, this compound actively hinders the phosphorylation and activation of STATs. The JAK-STAT signaling pathway is involved in the transcription of cells that are involved in hematopoiesis, and immune cell function. Tofajak tablet works therapeutically by causing inhibition against the JAK-STAT pathway to reduce the inflammatory response in the body. However, there is evidence to suggest that it may also achieve efficacy through other pathways also.

Medicine Interactions 

·         Phenobarbital

·         Adalimumab

·         Clozapine

·         Live attenuated vaccines and related products

Disease Interactions 

·         Hyperlipidemia

·         Infections

·         Tuberculosis

·         Hepatic impairment

·         Hepatitis B

Alcohol Interactions 

·         Interactions between the ingredients of Tofajak tablets and alcohol are not known. Please check with your doctor before consuming alcohol. 

Contraindications

Tofajak (Tofacitinib) tablets are contraindicated in the following cases:- 

·         Hypersensitivity 

·         Allergy to Tofacitinib

·         Allergy to inactive ingredients of the tablets

·         Patients aged below 18  

Alternative

Xeljanz
 

Side effects

Tofajak (Tofacitinib) tablets may cause side effects when administered to the patients. The following is a list of the same. 

  • Diarrhea 
  • Headache
  • Dizziness
  • Drowsiness 
  • Cough 
  • Trouble breathing 
  • Night sweats 
  • Sore throat 
  • Fever 
  • Chills 
  • Stomach pain 
  • Nausea 
  • Vomiting 
  • Itching 
  • Night sweats 
  • Dark urine 
  • Frequent urination
  • Redness on skin
  • Swelling on feet
  • Unusual tiredness 
  • Fatigue 
  • Body ache 
  • Weight gain 
  • Itching 
  • Irritation
  • Yellowing of the skin
  • Pale eyes 

Note:- Be sure to seek help from a medical practitioner if the condition worsens due to the side effects.

Dosage

The dose of Tofajak (Tofacitinib) tablets is recommended by the healthcare professional as per the patient’s health and requirements. These tablets are indicated for oral use. Swallow the tablets as a whole with water. 

Missed dose

If you miss a dose of Tofajak (Tofacitinib) tablets, make sure to call your healthcare professional to know the ways of managing the missed dose. Ask your doctor for methods of coping. 

Overdose

If symptoms of overdose occur, it becomes important to contact the nearest medical professional immediately for supportive care. Kindly do not ignore any symptoms. 

Warnings for Female

  • Pregnancy 
    • Tofajak (Tofacitinib) tablets are not recommended unless necessary in women who are pregnant or plan to get pregnant. Consult a medical professional. 
  • Breastfeeding 
    • Tofajak (Tofacitinib) tablets are not recommended unless necessary in women who are breastfeeding or plan to feed a child. Consult a medical professional.

Precautions 

  • Contraception 
    •  
  • Children and adolescents 
    • The safety and efficacy of Tofajak (Tofacitinib) tablets have not been established. Therefore, this medication is not indicated for use in patients below the age of 18 years.

Cautions

  • Do not crush or bite Tofajak (Tofacitinib) tablets,
  • Do not operate any machinery that requires concentration after taking Tofajak (Tofacitinib) tablets. 
  • Do not administer Tofajak (Tofacitinib) tablets in greater quantities. 
  • Do not store Tofajak (Tofacitinib) tablets in extreme temperatures. 

Q1. What is Tofajak (Tofacitinib)?

Ans. Tofajak tablets is a prescription regimen comprising Tofacitinib. It is used in the treatment of patients suffering from severely active rheumatoid arthritis and psoriatic arthritis.

Q2. How to use Tofajak (Tofacitinib)?

Ans. The dose of Tofajak (Tofacitinib) tablets is recommended by the healthcare professional as per the patient’s health and requirements. These tablets are indicated for oral use. Swallow the tablets as a whole with water. 

Q3. Does Tofajak (Tofacitinib) cause any side effects?

Ans. Tofajak (Tofacitinib) tablets can cause certain side effects like headache, fever, chills, skin rash, dizziness, drowsiness, loss of appetite, etc. 

Q4. What happens if I overdose on Tofajak (Tofacitinib)?

Ans. If symptoms of overdose occur, it becomes important to contact the nearest medical professional immediately for supportive care. Kindly do not ignore any symptoms. 

Q5. Is it safe to use Tofajak (Tofacitinib) during pregnancy?

Ans. Tofajak (Tofacitinib) tablets are not recommended unless necessary in women who are pregnant or plan to get pregnant. Consult a medical professional. 

Q6. Does Tofajak (Tofacitinib) affect kidney function?

Ans. Tofajak (Tofacitinib) tablets may affect the patients who are already suffering from any kidney disease. It is important to consult a doctor regarding the same. 

Q7. Can I drink alcohol after taking Tofajak (Tofacitinib)?

Ans. Interactions between the ingredients of Tofajak tablets and alcohol are not known. Please check with your doctor before consuming alcohol. 

Q8. In what strength is Tofajak (Tofacitinib) available?

Ans. Tofajak (Tofacitinib) is available in the form of oral-use tablets in the strength of 5mg by Cipla. 

Q9. Is it safe to use Tofajak (Tofacitinib) during breastfeeding?

Ans. Tofajak (Tofacitinib) tablets are not recommended unless necessary in women who are breastfeeding or plan to feed a child. Consult a medical professional.

Q10. What are the storage conditions of Tofajak (Tofacitinib)?

Ans. Store Tofajak (Tofacitinib) tablets at room temperature. Protect from light, heat, and moisture. 

Above Content has been reviewed by Professionals