SORAFENAT

Mfd. by :- Natco (Fulfilled By : Magicine Pharma)

Kidney cancer, Liver cancer, and Thyroid cancer Sorafenat

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Magicine Pharma is registered with the Government Of NCT, India, Ministry Of Health in Government of Delhi, India, registration number DL-RAJ-122372 and as a wholesale distributor, department file No. 44208.

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Brand Name:- Sorafenat 

Generic Name:- Sorafenib 

Manufacturer:- Natco 

Dosage Form:- Tablet

Strength:- 200mg 

Composition:- Sorafenib 

Packaging:- 120 tablet (120 / bottle) 

Indication:- Kidney cancer, Liver cancer, and Thyroid cancer

Storage:- Store at room temperature 

Overview

Sorafenat (Sorafenib) is used to treat a certain type of cancer (liver cancer, kidney cancer, and thyroid cancer). This tablet belongs to a class of medication known as a tyrosine kinase inhibitor. This medicine helps to stop the growth of cancerous cells. Take this medicine orally. Do not take this medicine in the wrong way as it may lead to some severe side effects. It is advisable not to change or stop the dose without taking suggestions from your doctor. If you experience any symptoms while receiving this medicine, inform your doctor immediately. Your doctor will decide the exact dosage of this medication. 

Pharmacodynamics of Sorafenat (Sorafenib)

Sorafenat is a kinase inhibitor that decreases tumor cell proliferation in vitro. Sorafenat inhibited tumor growth of HCC, RCC, and DTC human tumor xenografts in immunocompromised mice. Reductions in tumor angiogenesis were seen in models of HCC and RCC upon Sorafenat treatment, and increases in tumor apoptosis were observed in models of HCC, RCC, and DTC. 

After the oral administration, the effect of this medicine can be observed in 3 hours.

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Side effects of Sorafenat (Sorafenib)

This medicine may cause some major and minor side effects. It requires immediate medical attention otherwise it can also lead to higher risk. Discuss the risks and benefits of this medication with a medical advisor before starting the treatment. 

Common side effects 

  • Diarrhea 

  • Abdominal pain 

  • Fatigue

  • Coughing up blood 

  • Bleeding gums 

  • Nausea 

  • Bloating 

  • Difficulty in breathing 

  • Irregular heartbeat

  • Pale skin 

  • Seizures 

  • Sore throat 

  • Indigestion 

  • Hair loss 

  • Numbness 

  • Weight loss 

  • Dizziness 

  • Rash 

  • Joint pain 

  • Dry mouth

  • Dehydration 

  • Anemia 

  • Fainting 

  • Lightheadedness 

  • Muscle cramps 

  • Anxiety 

  • Itching 

  • Vomiting 

  • Tiredness 

  • Difficulty in swallowing 

  • Weakness 

  • Chest  pain 

  • Chills 

Note- Immediately contact your doctor, if any side effects occur  

Dosage

Take this medicine as prescribed by your doctor. Do not chew or crush the tablet. Take this medicine on an empty stomach. 

Missed dose 

  •  It is advisable not to miss a dose. If you miss a scheduled dose of Sorafenat tablet, contact your doctor immediately. 

Overdose 

  • In case of an overdose, the doctor will provide emergency medical treatment.

Usage of Sorafenat (Sorafenib)

Sorfenat tablet works by slowing down the growth of cancer cells. Take this medicine orally on an empty stomach once a day. Try not to miss your regular dosing schedule. Take this medicine as prescribed by your medical advisor. Do not crush or chew the tablet. The dose is decided by a medical advisor according to response to the treatment and your previous medical condition. Regular monitoring of blood pressure is required during treatment with this medicine.  Keep yourself hydrated and maintain good nutrition while having this medicine. 

Warnings 

Before starting treatment with Sorafenat, please inform your doctor about your previous medical history. If you experience any symptoms while receiving this medication, do not ignore those symptoms because it may lead to higher risk. 

 

  •  Contraception 

    • Use effective methods of contraception to prevent pregnancy while taking this medicine. 

  • Children and adolescents 

    • This medicine is not advisable for use in children and adolescents. 

Warnings for female 

  • Pregnancy 

    • Sorafenat tablets shouldn’t be used by pregnant women. Sorafenib may cause harm to the baby. It is recommended that this medicine should be avoided during pregnancy. 

 

  • Breastfeeding 

  • This medicine is not recommended in breastfeeding unless it is necessary. Please consult your medical advisor before starting treatment with this medication.

Precautions

  • Regular monitoring of blood pressure is required during the treatment with this medicine. 

  • This medicine may increase the risk of bleeding. 

  • This medicine should be used with caution in patients with low blood glucose levels. 

  • Consult a doctor if you are suffering from heart diseases.

  • This medication may cause dizziness. 

  • The use of this medicine may cause skin reactions.  

  • This medicine can reduce the number of white blood cells in the body. 

  • This medication may delay wound healing. 

Cautions

  • Do not drive or operate heavy machinery. 

  • Do not break, chew, or crush the medicine. 

  • Not safe for pregnant women. 

  • Do not breastfeed while receiving this medication. 

  • May harm liver 

Q1. What is Sorafenat (Sorafenib)? 

Ans. This medication is used to treat a certain type of cancer (liver cancer, kidney cancer, and thyroid cancer). This tablet belongs to a class of medication known as a tyrosine kinase inhibitor. This medicine helps to stop the growth of cancerous cells. 

Q2. How does Sorafenat (Sorafenib) work? 

Ans. Sorfenat tablet works by blocking the action of a protein that signals the cancer cells to multiply. This helps in slowing down the growth of cancer cells.

Q3. In what strength is it available? 

Ans. It is available in the strength of 200mg. 

Q4. What are the side effects? 

Ans. Some common side effects are:- nausea, irregular heartbeat, seizures, pale skin, abdominal pain, bleeding, diarrhea, fatigue, etc. 

Q5. What are self-care tips? 

Ans. Maintain good nutrition and keep yourself hydrated. 

Q6. What happens if I miss a dose? 

Ans. If you miss a scheduled dose of this medicine, contact your doctor immediately. 

Q7. Can I consume alcohol while taking this medicine? 

Ans. It is not known whether it is safe or not. Please consult your doctor before consuming alcohol. 

Q8. What should I avoid while receiving this medicine? 

Ans. Follow your doctor’s instructions about any restrictions on food and other activities.

Q9. Does this medicine affect liver function? 

Ans. Please contact your doctor before consuming this drug. 

Q10. Can I take this medicine during pregnancy?

Ans. This medicine is not recommended for pregnant women.

Q11. Can I drive after taking this medicine? 

Ans. This medicine may decrease your ability to drive or affect your vision. Do not drive if any symptoms occur. 

Q12. Can I take this medicine during breastfeeding? 

Ans. This medicine is not recommended in breastfeeding unless it is necessary.

Q13. How to take this medicine? 

Ans. Take this medicine on an empty stomach orally once a day. 

Q14. What are the storage conditions? 

Ans. Store this medicine at room temperature.

Interactions

Interactions may change how your medication works and increase the risk for side effects. Don’t forget to disclose your previous medical history with the doctor. 

Medicine interaction 

  • Amiodarone

  • Clozapine 

  • Moxifloxacin 

  • Bepridil 

  • Gatifloxacin 

  • Lomitapide 

  • Ziprasidone 

Disease interaction  

  • This medication should be used with caution in patients with a history of interstitial pneumonitis. 

Alcohol interaction 

  • Interaction with alcohol is unknown. Please contact your doctor before consuming alcohol. 

Contraindications

  • Sorafenat tablets are not recommended for use in patients with known allergy to Sorafenib.  

  • This medicine is contracted in patients known to be hypersensitive.

  • This medicine is not recommended for use in patients with squamous cell cancer.

Above Content has been reviewed by Professionals