Marketed By
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Pack of
10 Tablet
Salt Composition
Everolimus
Storage
Keep in cold place
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Evermil 5mg Tablet
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Overview
Evermil 5 mg Tablet is a medicine that combines cancer-fighting and immunosuppressing properties. Doctors prescribe it for advanced breast cancer, kidney cancer, and certain neuroendocrine tumors of the pancreas, lungs, or gut. It’s also used to help prevent organ rejection in patients who have undergone kidney or liver transplants and for specific conditions linked to tuberous sclerosis, such as SEGA or renal angiomyolipoma. The tablet should be taken exactly as directed, ideally at the same time each day, with or without food but consistently. Infections, anemia, exhaustion, diarrhea, mouth sores, excessive blood sugar, cough, and skin rashes are among the adverse effects that might occur despite its effectiveness. Evermil is not advised for children, pregnant women, or breastfeeding mothers due to its risks, and it needs constant medical supervision.
Indication
- Breast Cancer
- Kidney Cancer
- Neuroendocrine Tumors (NET)
- Organ Transplant
- Tuberous Sclerosis
Uses
- Breast Cancer
- Kidney Cancer
- Neuroendocrine Tumors (NET)
- Organ Transplant
- Tuberous Sclerosis
Side Effects
The human body shows undesired symptoms after taking Evermil 5mg Tablet. Usually, they disappear with time as the body adjusts to the medicine. It is advised to consult your doctor if these symptoms become unmanageable. Some of the side effects of Evermil Tablet are mentioned below:
- Difficulty breathing or swallowing
- Swelling of the face, lips, tongue, or throat
- Severe itching, red rash, or raised bumps
- Infection (chills, fever, or recurrent illness)
- Coughing, wheezing, or breathlessness
- Excessive thirst or abnormal urine output (too high or too low)
- Tiredness or fatigue
- Bleeding episodes
- Increased appetite with weight loss
- Elevated liver enzymes (alanine aminotransferase)
- High triglyceride levels in the blood
- Joint pain
- Pleural effusion (fluid around the lungs)
- Pulmonary edema (fluid in the lungs)
- Stomatitis (mouth inflammation or sores)
- Anemia (low red blood cell count)
- Low potassium levels in the blood
- Weight loss
- Changes in taste
- Rash or skin irritation
- Diarrhea
- Low blood platelets
- High blood sugar (increased glucose levels)
- Decreased appetite
How To Use
As directed by your physician, take this medication according to the prescription. Swallow the whole tablet with water. Avoid chewing, crushing, or breaking it. It is preferable to take the Evermil 5 Tablet at a set time, but it can be taken after or without food.
How It Works
Evermil 5mg Tablet works by stopping the activity of a protein known as a mammalian target of rapamycin (mTOR). This protein is responsible for cell growth and division. Evermil Tablet slows down the growth of cancerous cells by blocking the production of the mTOR protein. It also reduces the size of the tumor and prevents cancer from spreading to other parts of the body.
Safety Advice
Alcohol
CONSULT YOUR DOCTOR
Pregnancy
CONSULT YOUR DOCTOR
Breast Feeding
CONSULT YOUR DOCTOR
Driving
UNSAFE
Kidney
PRECAUTION
Liver
PRECAUTION
Missed Doses
It is advised not to miss any scheduled dosage of the Evermil 5 mg Tablet. In case you miss a dose, consult your doctor immediately. Don't overdose to compensate for the missed one.
Quick Tips
- Mouth sores are the most common side effect, so doctors often recommend using a dexamethasone oral rinse (instead of alcohol-based mouthwash) to help prevent them.
- Infections can happen more easily while on treatment, so it’s important to watch for signs like fever or chills.
- Non-infectious pneumonitis, which is lung inflammation not caused by infection, is a unique and serious side effect of mTOR inhibitors; it may require lowering the dose or even stopping the medicine.
- Metabolic changes such as high blood sugar or cholesterol levels can occur, so regular monitoring is advised.
- It is advised to use effective birth control ways and avoid pregnancy during the treatment with the Evermil 5 mg Tablet.
- A person should avoid smoking while undergoing treatment with the Evermil 5 mg Tablet. Smoking may reduce the effectiveness of medicine.
- Monitor your blood sugar & pressure, kidney & liver function (KFT & LFT), and heart function at proper intervals after taking the Evermil 5 mg Tablet.
- Swelling of hands and lips and weight gain are some of the side effects observed after taking the Evermil 5 mg Tablet. To reduce them, the doctor may suggest some medication.
- Skin becomes extremely sensitive after taking the Evermil 5 mg Tablet. It is advised to cover your skin exposed to direct sun rays and use high SPF sunscreen before going out.
- It is advised to avoid taking analgesics/antacids (medicines used to neutralize the stomach acid) while taking the Evermil 5 mg Tablet, as it may reduce the effectiveness of the medicine.
- Keep your body hydrated, as diarrhea is one of the common side effects experienced after taking the Evermil 5 mg Tablet. Consult your doctor if it doesn't stop or if blood appears in your stools.
- In case you notice symptoms like blurred vision, difficulty breathing, cough & fever, and diarrhea while taking the Evermil 5 mg Tablet, consult your doctor immediately before these symptoms become severe.
FAQs
Before starting Evermil 5 mg Tablet, it’s crucial to discuss your medical history, current medications, and lifestyle habits with your doctor, as the drug can interact with other medicines, affect immunity, and pose risks during pregnancy or breastfeeding.
Evermil 5 mg Tablet may cause side effects such as breathing difficulties, swelling, rash, infections, cough, fatigue, bleeding, mouth sores, changes in taste, diarrhea, anemia, low platelets, high blood sugar, liver enzyme changes, joint pain, fluid buildup in the lungs, and appetite or weight changes, so regular monitoring and medical supervision are essential.
No, a person should avoid any surgical procedure if taking Evermil Tablet. This medicine may result in poor wound-healing ability. It is advised to consult your doctor for more information.
Regularly monitor complete blood count (CBC), kidney function, liver function tests (LFT), blood glucose, and cholesterol levels.
Any person taking Evermil 5mg Tablet should avoid grapefruit or grapefruit juice. As this medicine may interrupt the effectiveness of the medicine.
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References
- Bengueddache, S., Cook, M., Lehmann, S., Arroyo, D., Togni, M., Puricel, S., & Cook, S. (2024). Ten-year clinical outcomes of everolimus- and biolimus-eluting coronary stents vs. Everolimus-eluting bioresorbable vascular scaffolds—Insights from the EVERBIO-2 trial. Frontiers in Cardiovascular Medicine, 11(4), 1426348 - https://pubmed.ncbi.nlm.nih.gov/39323753/
- Bingqi Zhuang, Chongning Zhong, Yuting Ma, Ao Wang, Hailian Quan, Lan Hong (2024). Innovative Therapeutic Strategies for Myocardial Infarction Across Various Stages: Non-Coding RNA and Stem Cells, International Journal of Molecular Sciences, 10.3390/ijms26010231, 26, 1, (231) - https://pmc.ncbi.nlm.nih.gov/articles/PMC11720039/
- De Simone, P., Precisi, A., Lai, Q., Ducci, J., Campani, D., Marchetti, P., & Gitto, S. (2024). Everolimus Mitigates the Risk of Hepatocellular Carcinoma Recurrence after Liver Transplantation. Cancers, 16(7), 1243 - https://pubmed.ncbi.nlm.nih.gov/38610921/
- Fort-Casamartina, E., Pernas, S., Otero, S., Mate, P., Gonzalo, N., Narváez, S., Rigo-Bonnin, R., Padró-Miquel, A., Teulé, À., Garcia del Muro, X., Peiró, I., Arribas, L., Esteve, A., Gonzalez, A., Rey, M., Clopés, A., Fontanals, S., & Muñoz, C. (2025). Everolimus Through Plasmatic Concentrations in Cancer Patients: Prospective Longitudinal Observational Multicentric Study (DIANA-1 Project). Journal of Clinical Medicine, 14(1), 145 - https://www.mdpi.com/2077-0383/14/1/145
- Gulati S, Tangen C, Ryan CW, et al. (2024) Adjuvant Everolimus in Non–Clear Cell Renal Cell Carcinoma: A Secondary Analysis of a Randomized Clinical Trial. JAMA Netw Open.7(8):e2425288 - https://pubmed.ncbi.nlm.nih.gov/39106067/
- Powles, T., Choueiri, T. K., Albiges, L., Peltola, K., de Velasco, G., Burotto, M., Suarez, C., Ghatalia, P., Iacovelli, R., Lam, E. T., Verzoni, E., Gümüş, M., Stadler, W. M., Kollmannsberger, C., Melichar, B., Venugopal, B., Gross‑Goupil, M., Poprach, A., De Santis, M., Rizzo, M., Shinde, R., Saretsky, T. L., He, L., Perini, R. F., & Vickery, D. (2025). Health‑related quality of life with belzutifan versus everolimus for advanced renal cell carcinoma (LITESPARK‑005): Patient‑reported outcomes from a randomized, open‑label, phase 3 trial. Lancet Oncology, 26(4), 491–502.
- Saliba F, Duvoux C, Dharancy S, Dumortier J, Calmus Y, Gugenheim J, Kamar N, Salamé E, Neau-Cransac M, Vanlemmens C, Durand F, Pageaux GP, Hardwigsen J, Benkhatar Y, Derquenne F, Conti F. (2025) Five-year outcomes in liver transplant patients receiving everolimus with or without a calcineurin inhibitor: Results from the CERTITUDE study. Liver Int. Nov;42(11):2513-2523.
- Taboada, R. G., Brito, A. B., Silva, A. L., Weschenfelder, R. F., & Riechelmann, R. P. (2024). The Efficacy of a Lower Dose of Everolimus in Patients with Advanced Neuroendocrine Tumors. Cancers, 16(22), 3773.
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Neha N.
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Amit Patel
Quality is outstanding
a year ago
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