PEGDOXINE

Mfd. by :- Arechar (Fulfilled By : Magicine Pharma)

Pegdoxine

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Magicine Pharma is registered with the Government Of NCT, India, Ministry Of Health in Government of Delhi, India, registration number DL-RAJ-122372 and as a wholesale distributor, department file No. 44208.

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Brand Name: Pegdoxine
Generic Name: Doxorubicin Pegylated Liposomal 
Manufacturer: Arechar 
Dosage Form: Injection 
Strength: 20mg
Composition: Doxorubicin pegylated liposomal 
Indication: Ovarian cancer, Kaposi’s sarcoma, and Multiple myeloma 
Storage: Store in refrigerator.

Overview

Pegdoxine (Doxorubicin Pegylated Liposomal) injection is used to treat certain types of cancer (ovarian cancer, AIDs related to Kaposi’s sarcoma, and multiple myeloma). This medication belongs to the group of antineoplastics (cancer-fighting medications) known as anthracyclines. Pegdoxine injection works by slowing or stopping the growth of cancer cells. It is important to take Pegdoxine as prescribed by your doctor. The recommended dose is decided by a healthcare provider according to your previous medical condition and response to the treatment. If you experience any signs and symptoms while receiving Pegdoxine medication, inform your doctor immediately. 

Pharmacodynamics

Doxorubicin Pegylated Liposomal Injection inhibits DNA and RNA synthesis by intercalating between DNA base pairs causing steric obstruction and inhibits topoisomerase-II at the point of DNA cleavage. Doxorubicin is also a powerful iron chelator. The iron-doxorubicin complex can bind DNA and cell membranes, producing free hydroxyl (OH) radicals that cleave DNA and cell membranes. Doxorubicin (liposomal) is a pegylated formulation that protects the liposomes and thereby increases blood circulation time.

Usage 

Pegdoxine injection an anti-cancer medication that is used for the treatment of Multiple myeloma, Ovarian cancer, and Kaposi’s sarcoma (a type of cancer that causes lesions to grow below the surface of the skin, lymph nodes, etc).  This medication affects your immune system and weakens your body to fight against infections. Do not take Pegdoxine injection in the wrong way as it may lead to some serious side effects. It is advised not to change your regular dosing schedule without taking suggestions from your doctor. Follow the instructions given by your healthcare provider to avoid any further complications. 

Interactions

Pegdoxine injection can interact with other medications and it may increase the risk for side effects. Don’t forget to disclose and discuss your previous medical history with the doctor.

Medicine Interactions

  • Adalimumab 

  • Cladribine 

  • Fingolimod 

  • Infliximab

  • Mifepristone 

  • Ozanimod  

  • Vandetanib 

Disease Interactions

  • Hepatic dysfunction 

  • Myelosuppression 

  • Infections 

  • Cardiomyopathy 

Alcohol Interaction 

  • Interaction with alcohol is unknown. Please consult your doctor before consuming alcohol.

Contraindication 

  • Do not take this medicine if you are allergic to Doxorubicin pegylated.

  • Pegdoxine injection is not recommended in patients known to be hypersensitive.

Alternate Brands

Side effects

This medicine may cause some common side effects. Discuss the risks and benefits of Pegdoxine injection with the doctor before starting the treatment.

Common side effects 

  • Severe headache 

  • Rash 

  • Sore throat 

  • Nausea 

  • Fever 

  • Vomiting 

  • Pain at the injection site 

  • Dizziness 

  • Muscle pain 

  • Diarrhea 

  • Hair loss 

  • Cough 

  • Loss of appetite 

  • Constipation 

  • Blisters 

  • Anxiety 

  • Shortness of breath 

  • Tiredness

  • Abdominal pain 

  • Chest pain 

  • Shortness of breath 

  • Irregular heartbeat 

  • Back pain 

  • Difficulty in urination 

  • Pale skin

  • Fever with chills 

  • Dehydration 

  • Mouth ulcers 

  • Painful blisters on hand and feet 

  • Low blood pressure 

  • Pin when eating and swallowing 

  • Red spots on the skin 

  • Drowsiness 

  • Low red and white blood cells 

  • Blurred vision 

  •  Red and itchy eyes 

Note - immediately contact your healthcare provider if any side effects occur.

 

Dosage 

Take this injection as prescribed by your doctor. Your healthcare provider will give you Pegdoxine injection according to your medical condition.

Missed dose 

  • It is advisable not to miss a dose. If you miss an appointment for a scheduled dose of Pegdoxine injection, contact your doctor immediately. 

Overdose 

  • In case of an overdose of Pegdoxine injection, the doctor will provide emergency medical treatment.

Warnings 

Before starting treatment with Pegdoxine medicine, please inform your doctor about your previous medical history. If you experience any signs and symptoms while receiving this medication, do not ignore those symptoms because it may lead to higher risk. 

 

  •  Contraception 

    • Use effective methods of contraception to prevent pregnancy while taking this medicine. 

  • Children and adolescents 

    • This medicine is not advisable for use in children and adolescents.

Warnings for female 

  • Pregnancy

    • Do not use Pegdoxine medicine if you are planning to become pregnant. Avoid this medication at the time of pregnancy. 

  • Breastfeeding

    • Pegdoxine injection is not recommended in breastfeeding unless it is required. Please consult with your healthcare provider before starting treatment with this medication. 

 

Precautions 

  • Close monitoring of blood cell count and body temperature is necessary while receiving this medication. 

  • Pegdoxine injection may increase the risk of heart failure. 

  • Do not receive any vaccines while having treatment with this medicine. 

  • The use of this medication may decrease the white blood cell count in some patients. 

  • Avoid contact with people who have infections. 

  • Close monitoring of symptoms like mouth ulcers and bleeding is required. 

Cautions 

  • Do not shake or freeze the vial.

  • Do not drive or operate heavy machinery. 

  • Do not self-administer this medicine.

  • Not safe for pregnant women.

  • Do not breastfeed while receiving this medication. 

  • Do not start the treatment with Pegdoxine medication if the blood cell count is low.

Q1. What is Pegdoxine (Doxorubicin pegylated liposomal)? 

Ans. This is an anti-cancer drug that belongs to a class of medication like anthracyclines. Pegdoxine medication works by slowing or stopping the growth of cancer cells.

Q2. How does Pegdoxine work? 

Ans. This medication works by restructuring the activity of an enzyme called topoisomerase II that helps cancer cells to divide and grow. 

Q3. What are the side effects? 

Ans. Some common side effects are:- severe headache, nausea, sore throat, vomiting, dehydration, anxiety, chest pain, rash, irregular heartbeat, shortness of breath, etc. 

Q4. How to take this medicine?

Ans. It is advisable to not self-administer Pegdoxine injection. Your healthcare provider will give you this injection according to your medical condition.

Q5. What happens if I miss a dose? 

Ans. If you miss a scheduled dose of Pegdoxine injection, contact your doctor immediately.

Q6.  Can I take this medicine during pregnancy? 

Ans. This medication is not recommended during pregnancy.

Q7. In what strength is it available? 

Ans. Pegdoxine injection is available in the strength of 20mg.

Q8. What should I avoid while receiving Pegdoxine? 

Ans. Avoid activities that may increase the risk of bleeding and follow the advice of your healthcare provider about any restrictions on food and other activities.

Q9. Can I drive after taking this medicine? 

Ans. Pegdoxine injection may decrease your ability to drive or affect your vision. Do not drive if any symptoms occur.

Q10. Can I consume alcohol while taking Pegdoxine injection? 

Ans. Please consult your doctor before consuming alcohol. 

Q11. Does this medicine affect liver function? 

Ans. Please consult your doctor before consuming this drug. 

Q12. What are the storage conditions?

Ans. Store this medicine in the refrigerator. Do not shake or freeze the vial.

 

Above Content has been reviewed by Professionals