Brand name - Mozifor
Generic name - Plerixafor
Manufacturer - Hetero Drugs Ltd
Salt composition - Plerixafor (24mg)
Storage - Store at room temperature (10-30°C)
Dosage form - Injection
Strength - 1.2 ml
Packaging - Vial
Gender - Unisex
Indication - Used in the treatment of Multiple myeloma, Non-hodgkin’s lymphoma and other related conditions
Mozifor injection is used in the treatment of Multiple myeloma, Non-hodgkin’s lymphoma, and other related conditions. It is used in Autologous stem cell transplant. In this procedure, certain blood cells are removed from the body and then returned back to the body after the chemotherapy and/or radiation in patients with certain types of cancers.
Plerixafor is an hematopoietic stem cell mobilizer. It works by moving certain blood cells from the bone marrow to the blood so that those cells can be removed for transplant. Plerixafor is an inhibitor of the CXCR4 chemokine receptor. It blocks the binding of its cognate ligand, stromal cell-derived factor-1α (SDF-1α). SDF-1α & CXCR4 play a role in the trafficking & homing of human hematopoietic stem cells (HSCs) to the marrow compartment. Once in the marrow, stem cell CXCR4 can work to help anchor these cells to the marrow matrix, either directly via SDF-1α or through the induction of other adhesion molecules. Treatment with Plerixafor resulted in leukocytosis and elevations in circulating hematopoietic progenitor cells in humans. CD34+ cells mobilized by Plerixafor are capable of engraftment with long-term repopulating capacity up to one year in canine transplantation models.
Data on the fold increase in peripheral blood CD34+ cell count (cells/mcL) by apheresis day was evaluated in two placebo-controlled clinical studies in patients with NHL and MM. The fold increase in CD34+ cell count (cells/mcL) over the 24-hour period starting from the day prior to the first apheresis and ending the next morning just before the first apheresis was noted. During this 24-hour period, a single dose of placebo was administered 10 to 11 hours prior to apheresis.
Peak mobilization of CD34+ cells was observed between 6 and 9 hours after administration. A sustained elevation in the peripheral blood CD34+ count was observed from 4 to 18 hours after plerixafor administration with a peak CD34+ count between 10 and 14 hours.
The active ingredient in Mozifor is Plerixafor.
Usage of Mozifor (Plerixafor)
Mozifor injection is used in the treatment of Multiple myeloma, Non-hodgkin’s lymphoma and other related conditions. It is used in Autologous stem cell transplant.
Plerimob 24mg Injection
Common side effects
Injection site reactions
Serious side effects
Your healthcare provider will decide your dose according to your medical condition and requirement.
Do not take the missed dose if it is already time for the next dose. Do not double the dose to catch up.
Please consult your healthcare provider regarding any symptoms of overdose.
Warning and precautions
Avoid driving or operating machines as this medicine may cause dizziness and vomiting.
Tell your healthcare provider if you have any allergy or liver disease or kidney disease or if you take any other medication.
Please consult your healthcare provider regarding the consumption of Mozifor injection during breastfeeding.
Tell your healthcare provider if you are planning to get pregnant or breastfeeding.
Q1- What is Mozifor?
A- Mozifor injection is used in the treatment of Multiple myeloma, Non-hodgkin’s lymphoma and other related conditions.
Q2- How should I take Mozifor?
A- Your healthcare provider will give you this medicine. Kindly do not self administer.
Q3- What are the possible side effects of Mozifor?
A- There can be side effects such as diarrhea, nausea, fatigue, headache, dizziness, vomiting and injection site reaction. Please consult your healthcare provider if you experience these or any other side effects.
Q4- In what strength is it available?
A- It is available in the strength of 1.2ml.
Q5- What happens if I miss a dose?
A- If it is already time for the next dose, do not take the previous dose. Do not double the dose to catch up. Also, inform your healthcare provider.
Q6- What should I avoid while consuming this medicine?
A- Avoid drinking alcohol.
Q7- What are self care tips?
A- Note every side effect and consult your healthcare provider for the same as soon as you can.
Q8 Can I take this medicine during pregnancy?
A- Mozifor injection may cause harm to the developing baby. Please consult your healthcare provider for the same.
Q9- Can I drive after taking this medicine?
A- Mozifor injection may make you drowsy. Avoid driving and operating heavy machines.
Q10- What are the storage conditions?
A- Store at room temperature (10-30°C).
Q11- Is it safe to take Mozifor injection in liver disease?
A- There is not much information available about this medicine with respect to liver disease. Please consult your healthcare provider.
Q12- Is it safe to take Mozifor injection with kidney disease?
A- In patients with kidney disease, Mozifor injection’s dose may be adjusted. Please consult your healthcare provider for the appropriate dose details.
Q13- Is it safe to consume alcohol with Mozifor injection?
A- It is not known whether it is safe to consume alcohol with Mozifor injection. Please consult your healthcare provider.